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KMID : 0355220100350040229
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Journal of Korean Academy Oral Medicine
2010 Volume.35 No. 4 p.229 ~ p.235
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A Study for Direct Application of Drug on Oral Mucosa
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Jeong Su-Min
Ok Soo-Min
Heo Jun-Young
Ko Myung-Yun
Ahn Yong-Woo
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Abstract
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A common method for treating oral mucosal diseases is taking medication by oral administration. The oral administration is the method of least resistance. Because large part of drugs is degraded by liver, it is necessary to take more drugs getting to appropriate level in blood stream. And there are so many side effects when patients take drugs by oral administration.
In so many cases, the patients who suffer from oral mucosal problems have the other general diseases simultaneously. Willingly or not, some patients can"t take the medicine by oral administration.
Number of topical drugs for oral mucosal disease is less than that for skin diseases because the environment of oral mucosa prevents activity of medicine.
In this paper, research on effects of topical type medication for treating oral mucosal diseases is conducted through investigating currently used medications and their effects. In addition, effects of dissolved oral medications with appropriate solvent are demonstrated if this medication is useful for patients clinically.
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KEYWORD
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Oral mucosa, Drug, Topical application, Transdermal drug delivery system
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